Neuregulin - CISMeF

Preferred Label : Neuregulin;

NCIt synonyms : ARIA; Heregulin; Neu-Differentiation Factor; Sensory-and-motor-derived factor; Glial Growth Factor; NDF; GGF;

NCIt definition : Neuregulin (heregulin) polypeptides have been shown to interact with and activate the ErbB2, ErbB3 and ErbB4 receptor proteins, and have been found to be essential for the normal development of the cardiovascular, pancreatic and nervous systems. Neuregulins are involved in the normal development of mammary gland, are secreted by breast cancer cells, and can alternatively promote or inhibit breast cancer cell division.;

Details

Origin ID

C20433;

UMLS CUI

C0752253;

Automatic exact mappings (from CISMeF team)
- ARIA [MedDRA LLT]
- ARIA-E [MedDRA LLT]
- Endothelial cell surface-expressed chemotaxis and apoptosis regulator [OMIM gene]
- Neuregulin 1 [OMIM gene]
- Neuregulin-1 [MeSH Descriptor]
Currated CISMeF NLP mapping
- glial growth factor [MeSH concept]
- heregulin [MeSH concept]
- neu differentiation factor [MeSH concept]
- neuregulins [MeSH Descriptor]
- neuregulins [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hormone [UMLS semantic type]
UMLS correspondences (same concept)
- neuregulins [MeSH concept]
- neuregulins [MeSH Descriptor]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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