Preferred Label : Cisplatin Nano-engineered Intraoperative System PRV211;
NCIt synonyms : Cisplatin Nanoparticles-containing Intraoperative Formulation PRV211; Cisplatin Nano-engineered Intraoperative Formulation PRV211; Cisplatin Nano-engineered Formulation PRV211; Nano-engineered Hydrogel PRV211; Nano-engineered Polymeric Patch PRV211; Intraoperative Cisplatin System PRV211;
NCIt definition : A nano-engineered intraoperative system containing a liquid permeation enhancer (PE)
and a patch composed of nanoparticles loaded with the inorganic platinum agent cisplatin,
with potential antineoplastic and immunomodulating activities. Immediately following
surgical tumor resection, the cisplatin nano-engineered intraoperative system PRV211
is applied intraoperatively; the PE is brushed onto the resected tumor bed and then
the cisplatin patch is applied onto the same tumor site. Upon subsequent long-lasting
and controlled release from the patch and penetration into the tumor bed, cisplatin
forms highly reactive, charged, platinum complexes which bind to nucleophilic groups
such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links,
as well as DNA-protein cross-links. These cross-links result in apoptosis and growth
inhibition of tumor cells. Cisplatin may reach regional lymph nodes and may trigger
anti-tumor immune responses. Administration of PRV211 may eliminate any remaining
micro metastases or close margins that could not be fully resected while avoiding
system circulation. This may prevent systemic side effect and cancer recurrence.;
Molecule name : PRV-211; PRV 211;
NCI Metathesaurus CUI : CL1926741;
Origin ID : C204213;
UMLS CUI : C5908045;
Semantic type(s)
- concept_is_in_subset
