Peroxisomal ATPase PEX1

Preferred Label : Peroxisomal ATPase PEX1;

NCIt synonyms : PEX1; Peroxin-1; Peroxisome Biogenesis Factor 1; Peroxisomal Biogenesis Factor 1; Peroxin 1; EC 3.6.4.-; Peroxisome Biogenesis Disorder Protein 1;

NCIt definition : Peroxisomal ATPase PEX1 (1283 aa, 143 kDa) is encoded by the human PEX1 gene. This protein plays a role in ATP-dependent extraction of peroxisomal targeting signal 1 receptor (PEX5) from the peroxisomal membrane.;

NCIt note : Peroxisomal ATPase PEX1 is a homooligomer in the cytosol until it interacts with peroxisomal ATPase PEX6. Interaction with PEX6 dissociates PEX1 homooligomers and promotes formation of the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by three of PEX1-PEX6 heterodimers. The recruitment of PEX1-PEX6 AAA ATPase complex to peroxisome membranes is promoted by interaction with peroxisome assembly protein 26 (PEX26). (UniProt);

Details

Origin ID

C204211;

UMLS CUI

C0673929;

OMIM relation
- Peroxisome biogenesis factor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PEX1 protein, human [MeSH Supplementary Concept]
- PEX1 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- PEX1 Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Cytoplasm [NCIt concept]
- Membrane of the Peroxisome [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Peroxisome Biogenesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- ATP Hydrolysis [NCIt concept]
- Hydrolysis [NCIt concept]
- Ligand Binding [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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