Preferred Label : IL-15(N72D)/IL-15Ralpha-sFc Fusion Protein Complex FL115;
NCIt synonyms : IL-15(N72D)/IL-15Ra-sFc Fusion Protein Complex FL115; IL-15 Agonist Fusion Protein FL115;
NCIt definition : A long-acting form of the cytokine interleukin (IL)-15 and a fusion protein complex
composed of a mutated form of IL-15, with an asparagine to aspartic acid substitution
at amino acid 72 (N72D) (IL-15N72D), complexed with a soluble IL-15 receptor alpha
(IL-15 Ralpha; IL-15Ra) Fc domain (IL-15Ra-sFc) (IL-15N72D/IL-15Ra-sFc), with potential
antineoplastic activity. Upon administration, IL-15(N72D)/IL-15Ra-sFc fusion protein
complex FL115 targets and binds to the IL-2/IL-15 receptor beta-common gamma chain
(IL-2Rbetagamma) receptor on natural killer (NK) and CD8 T-lymphocytes, which activates
and increases the levels of NK cells and memory CD8 (CD44high) T-cells. The memory
T-cells enhance the secretion of the cytokine interferon-gamma (IFN-g), which further
potentiates the immune response against tumor cells. This may increase tumor cell
killing and decrease tumor cell proliferation. IL-15 regulates CD8 T and NK cell
development, activation and proliferation. By coupling IL-15 to IL-15Ra-sFc, this
agent has a prolonged drug half-life and shows an increased ability to bind IL-2Rbetagamma,
which enhances its immune stimulatory activity as compared to IL-15 alone.;
Molecule name : FL 115; FL-115;
NCI Metathesaurus CUI : CL1926424;
Origin ID : C204177;
UMLS CUI : C5908042;
Semantic type(s)
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
