Anti-HHLA2 Monoclonal Antibody NPX887

Preferred Label : Anti-HHLA2 Monoclonal Antibody NPX887;

NCIt synonyms : Anti-HHLA-2 Monoclonal Antibody NPX887; Anti-B7-H7 Monoclonal Antibody NPX887;

NCIt definition : A human immunoglobulin G1 (IgG1) monoclonal antibody directed against HERV-H LTR-associating protein 2 (HHLA2; HHLA-2; B7 homolog 7; B7-H7), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-HHLA2 monoclonal antibody NPX887 targets and binds to HHLA2, and blocks the interaction between HHLA2 and its receptors. This abrogates the HHLA2-mediated inhibition of T-cell and nature killer (NK) cell activation, which may lead to enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response and NK cell cytotoxicity against cancer cells. HHLA2, a member of the B7 family of immune modulators, is upregulated in a variety of tumor cell types and a negative regulator of T-cell and NK cell activation.;

Molecule name : NPX 887; NPX-887;

NCI Metathesaurus CUI : CL1926416;

Details

Origin ID

C204125;

UMLS CUI

C5908029;

Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- HERV-H LTR-Associating Protein 2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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