Preferred Label : Radicicol Derivative KF58333;
NCIt synonyms : (1aR,2Z,4E,6E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione
6-[O-[2-(2-Oxo-1-pyrrolidinyl)ethyl]oxime];
NCIt definition : A novel oxime derivative of radicicol that destabilizes the hsp90 client proteins,
such as erbB2, raf-1 and AKT, which are essential for tumor cell growth and survival.
(NCI);
CAS number : 308244-21-5;
Molecule name : KF-58333;
Codes from synonyms : 50598;
Origin ID : C2041;
UMLS CUI : C1136632;
Semantic type(s)
- UMLS correspondences (same concept)
- KF58333 [MeSH Supplementary Concept]
- chemical_or_drug_has_physiologic_effect
