Preferred Label : VAV Family Gene;
NCIt definition : VAV Family Genes (VAV1, VAV2, and VAV3) encode VAV proteins that respond to similar
cell surface receptor tyrosine kinases as GEFs for Rho/Rac family GTPases, which activate
pathways leading to actin cytoskeletal rearrangements, transcriptional alterations,
cell differentiation, and/or cell proliferation. VAV proteins contain CH, DH, PH,
SH2, SH3, and zinc-dependent phorbol-ester and DAG binding domains. VAV1 is expressed
exclusively in hematopoietic cells, while VAV2 and VAV3 are more broadly expressed.
(NCI);
Origin ID : C20408;
UMLS CUI : C1336928;
Semantic type(s)
- gene_found_in_organism
- gene_plays_role_in_process
