Preferred Label : Synergistic Effect;
NCIt definition : Two or more drugs working together to produce an effect markedly greater than either
individual drug's effect.;
Alternative definition : CDISC-GLOSS: An interaction between bioactive compounds or drugs that is deemed greater
than the sum of each individual component. NOTE: The terms additivity, synergism,
and antagonism should be used with care, unless the specific pharmacological pathways
or mechanisms of action of the investigated drugs are known. [After Calzetta L, Koziol-White
C. Pharmacological interactions: Synergism, or not synergism, that is the question.
Curr Res Pharmacol Drug Discov. 2021 Aug 11;2:100046.] See also synergistic effect,
antagonistic effect, drug interaction.; MRCT-Ctr: When two or more things combined have a greater effect than when their individual
effects are added together. (https://mrctcenter.org/glossaryterm/synergistic-effect/);
NCI Metathesaurus CUI : CL1926275;
Origin ID : C203931;
UMLS CUI : C5909503;
Semantic type(s)
- concept_is_in_subset
