Preferred Label : ORC Subunit Gene;
NCIt definition : DNA replication is initiated by the Origin Recognition Complex (ORC). ORC is composed
of six protein subunits and binds to the ARS Consensus Sequence (ACS) of Origins of
Replication in an ATP-dependent manner. While ORC remains bound to origins throughout
the cell cycle, the binding of ORC and other factors modulates local chromatin structure
to facilitate replication initiation. All 6 genes encoding ORC (ORC1 through ORC6)
may be required for initiation of DNA replication and are essential for viability.;
Origin ID : C20371;
UMLS CUI : C1335089;
Semantic type(s)
- gene_found_in_organism
- gene_plays_role_in_process
