Cobalamin Binding Intrinsic Factor

Preferred Label : Cobalamin Binding Intrinsic Factor;

NCIt synonyms : Transcobalamin 3; IF; Cobalamin-Binding Intrinsic Factor; INF; CBLIF;

NCIt related terms : TCN3; INTRINSIC FACTOR; GIF; Gastric Intrinsic Factor;

NCIt definition : Cobalamin binding intrinsic factor (417 aa, 45 kDa) is encoded by the human CBLIF gene. This protein is involved in the absorption of cobalamin into cells of the digestive tract.;

Alternative definition : CDISC: A glycoprotein encoded by the CBLIF gene, produced by the parietal cells in the stomach, and is necessary for the absorption of vitamin B12 (cobalamin) in the distal ileum of the small intestine. It can be considered as an autoantigen and is commonly associated with the autoimmune disease pernicious anemia.;

NCI Metathesaurus CUI : CL1927113;

Details

Origin ID

C203624;

UMLS CUI

C5890942;

OMIM relation
- Cobalamin-binding intrinsic factor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- CBLIF Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Transcobalamin [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Endocytotic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Binding [NCIt concept]
- Transmembrane Transport [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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