Preferred Label : Fluorine F 18-labeled MeFAMP;
NCIt synonyms : (R)-3-[F-18]fluoro-2-methyl-2-(methylamino)propanoic Acid; Fluorine F 18 MeFAMP; 18F-MeFAMP; 3-[18F]fluoro-2-methyl-2-N-(methyl amino) Propanoic Acid; [F-18]MeFAMP;
NCIt definition : A radioconjugate composed of the non-natural amino acid (R)-3-fluoro-2-methyl-2-(methylamino)propanoic
acid (MeFAMP) radiolabeled with the positron-emitting isotope fluorine F 18, with
potential cancer cell imaging activity during positron emission tomography (PET).
Due to their altered metabolic states, tumor cells have a higher rate of protein synthesis
than normal, healthy cells and, upon administration, fluorine F 18-labeled MeFAMP
is selectively taken up by rapidly proliferating tumor cells through the membrane-associated
amino acid transport system (AAT). It is neither incorporated into proteins nor readily
degraded, resulting in the accumulation of this imaging agent in tumor cells. Upon
PET, tumor cells can then be visualized.;
NCI Metathesaurus CUI : CL1922693;
Origin ID : C203516;
UMLS CUI : C4041639;
Semantic type(s)
- concept_is_in_subset
