Preferred Label : Tolododekin Alfa;
NCIt synonyms : Aluminum Hydroxide-anchored IL-12 ANK-101; Anchored Drug Complex ANK-101; Anchored IL-12 ANK-101; HIL-12-ABP; Engineered IL-12 Variant/Aluminum Hydroxide Complex ANK-101;
NCIt definition : An anchored drug complex-based formulation consisting of an engineered variant of
the cytokine interleukin-12 (IL-12) linked to an inert scaffolding composed of aluminum
hydroxide, with potential immunomodulatory and antineoplastic activities. Upon intratumoral
administration of tolododekin alfa, the IL-12 moiety activates the immune system by
promoting the secretion of interferon-gamma (IFN-g) and activating CD8 T-cells, CD4
T-cells and natural killer cells (NKs) in the tumor microenvironment (TME). The activation
and expansion of these immune cells mediate cytolytic immune responses against tumor
cells, thereby killing tumor cells and inhibiting tumor cell proliferation. The linking
of IL-12 to aluminum hydroxide reduces the clearance of IL-12 from the tumor, prevents
systemic accumulation of IL-12 and allows local and sustained accumulation of IL-12,
thereby prolonging the half-life and reducing systemic toxicities.;
UNII : HEZ9892GNP;
CAS number : 3028474-00-9;
Molecule name : ANK 101; ANK-101;
NCI Metathesaurus CUI : CL1922704;
Origin ID : C203514;
UMLS CUI : C5908006;
Semantic type(s)
- concept_is_in_subset
