Preferred Label : Engineered IL-12 Variant/Aluminum Hydroxide Complex ANK-101;
NCIt synonyms : Aluminum Hydroxide-anchored IL-12 ANK-101; Anchored Drug Complex ANK-101; Anchored IL-12 ANK-101;
NCIt definition : An anchored drug complex-based formulation consisting of an engineered variant of
the cytokine interleukin-12 (IL-12) linked to an inert scaffolding composed of aluminum
hydroxide, with potential immunomodulatory and antineoplastic activities. Upon intratumoral
administration of engineered IL-12 variant/aluminum hydroxide complex ANK-101, IL-12
activates the immune system by promoting the secretion of interferon-gamma (IFN-g)
and activating CD8 T-cells, CD4 T-cells and natural killer cells (NKs) in the tumor
microenvironment (TME). The activation and expansion of these immune cells mediate
cytolytic immune responses against tumor cells, thereby killing tumor cells and inhibiting
tumor cell proliferation. The linking of IL-12 to aluminum hydroxide reduces the clearance
of IL-12 from the tumor, prevents systemic accumulation of IL-12 and allows local
and sustained accumulation of IL-12, thereby prolonging the half-life and reducing
systemic toxicities.;
Molecule name : ANK 101; ANK-101;
NCI Metathesaurus CUI : CL1922704;
Origin ID : C203514;
UMLS CUI : C5908006;
Semantic type(s)
- concept_is_in_subset
