Preferred Label : CDC7 Inhibitor SGR-2921;
NCIt definition : An orally bioavailable small molecule inhibitor of cell division cycle 7-related protein
kinase (CDC7), with potential antineoplastic activity. Upon oral administration, CDC7
inhibitor SGR-2921 targets, binds to and inhibits the activity of CDC7, which may
result in an impaired response to replication stress, DNA damage, and the induction
of tumor cell apoptosis. CDC7, a serine-threonine kinase overexpressed in a variety
of tumor cell types, plays a key role in DNA replication and DNA damage response by
binding to and phosphorylating serine (Ser)-40 and 53 of minichromosome maintenance
complex component 2 (MCM2).;
Molecule name : SGR 2921; SGR-2921;
NCI Metathesaurus CUI : CL1922610;
Origin ID : C203417;
UMLS CUI : C5908001;
Semantic type(s)
- concept_is_in_subset
- has_target
