Preferred Label : Anti-BCMA/Anti-GPRC5D CAR-T Cells BMS-986453;
NCIt synonyms : Anti-GPRC5D/Anti-BCMA CAR-T Cells BMS-986453; BCMAxGPRC5D CAR T Cells BMS-986453; Anti-BCMA/GPRC5D CAR T-cells BMS-986453;
NCIt definition : A preparation of T-lymphocytes engineered to express chimeric antigen receptor(s)
(CAR) targeting the human tumor-associated antigens (TAAs) B-cell maturation antigen
(BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and G-protein
coupled receptor family C group 5 member D (GPRC5D), with potential immunostimulating
and antineoplastic activities. Upon administration, anti-BCMA/anti-GPRC5D CAR-T cells
BMS-986453 specifically and simultaneously target and bind to tumor cells expressing
BCMA and/or GPRC5D. This induces selective toxicity in tumor cells that express BCMA
and/or GPRC5D. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and
B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor
superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed
on malignant plasma cells and plays a key role in plasma cell proliferation and survival.
GPRC5D is overexpressed in certain malignancies, such as multiple myeloma, while minimally
expressed in normal, healthy cells. It plays a key role in tumor cell proliferation.;
Molecule name : BMS-986453; BMS 986453;
NCI Metathesaurus CUI : CL1922060;
Origin ID : C203328;
UMLS CUI : C5907997;
Semantic type(s)
- concept_is_in_subset
- has_target
