Preferred Label : Anti-CEACAM5 ADC SGN-CEACAM5C;
NCIt synonyms : Anti-CEACAM5 Antibody-drug Conjugate SGN-CEACAM5C; Anti-CEA ADC SGN-CEACAM5C; Antibody-drug Conjugate SGN-CEACAM5C;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) carcinoembryonic antigen (CEA; carcinoembryonic
antigen-related cell adhesion molecule 5; CEACAM5; CD66e) and conjugated to a cytotoxic
camptothecin-based payload, with potential antineoplastic and immune checkpoint inhibitory
activities. Upon administration of anti-CEACAM5 ADC SGN-CEACAM5C, the monoclonal antibody
moiety targets and binds to CEA expressed on tumor cells. Upon binding and internalization,
the payload is released. The camptothecin payload inhibits DNA topoisomerase I activity,
thereby inhibiting DNA replication and resulting in cell cycle arrest and tumor cell
apoptosis. This inhibits the proliferation of CEA-expressing tumor cells. CEA, a member
of the CEA family of proteins that plays a key role in cell migration, cell invasion,
and cell adhesion, is overexpressed by a variety of cancer cell types. Its expression
is limited in normal. healthy, adult tissues, but is overexpressed in various cancers.;
Molecule name : SGN-CEACAM5C; SAR-445953; SGN CEACAM5C; SAR 445953;
Origin ID : C203326;
concept_is_in_subset
- has_target
