Preferred Label : TACC3 Protein-Protein Interaction Inhibitor AO-252;
NCIt synonyms : TACC3 PPI Inhibitor AO-252;
NCIt definition : An orally bioavailable protein-protein interaction (PPI) inhibitor that targets transforming
acidic coiled-coil-containing protein 3 (TACC3), with potential antineoplastic activity.
Upon oral administration, TACC3 PPI inhibitor AO-252 targets and inhibits the interactions
of TACC3 with its protein partners, including clathrin/KIFC1, BARD1 and MBD2/HAT complexes.
This may inhibit tumor cell growth. TACC3 plays an important role in the regulation
of mitosis, DNA damage response and epigenetic functions via its interaction with
its protein partners.;
Molecule name : AO-252; AO 252;
NCI Metathesaurus CUI : CL1922034;
Origin ID : C203268;
UMLS CUI : C5907995;
Semantic type(s)
- concept_is_in_subset
- has_target
