NCIt definition : A bispecific antibody directed against both the mutated form of calreticulin (CALRmut;
mutCALR) and the T-cell surface antigen CD3, with potential immunostimulating and
antineoplastic activities. Upon administration, anti-CALRmut/anti-CD3 bispecific antibody
JNJ-88549968 targets and binds to both CALRmut expressed on CALR mutated CD34-positive
hematopoietic stem cells (HSCs) and CD3 on T-cells. This results in the cross-linking
of CALRmut-expressing tumor cells and T-cells, and induces a cytotoxic T-lymphocyte
(CTL) response against CALRmut-expressing tumor cells. CALR mutations, either insertions
or deletions in exon 9, result in a frameshift that causes the loss of the KDEL ER
retention motif. CALR mutations drive a variety of myeloproliferative neoplasms (MPNs).;
Semantic type(s)