Preferred Label : Dencatistat;
NCIt synonyms : Cytidine Triphosphate Synthase 1 Inhibitor STP938; CTPS1-IN-2; CTPS1 Inhibitor STP938;
NCIt definition : An orally bioavailable, small molecule inhibitor of cytidine triphosphate synthase
1 (CTPS1), with potential antineoplastic activity. Upon oral administration, dencatistat
targets, binds to and inhibits the activity of CTPS1, thereby decreasing the production
of cytidine triphosphate (CTP), an essential building block of deoxyribonucleic acid
(DNA) and ribonucleic acid (RNA). This may disrupt DNA and RNA synthesis and trigger
apoptosis. CTPS1, an enzyme that catalyzes the rate-limiting step in pyrimidine synthesis,
plays an important and nonredundant role in B-cell and T-cell proliferation. CTPS1
is required for rapid cell division in certain types of cancers that arise from blood
cells.;
UNII : QG9C9SZZ3T;
CAS number : 2377000-84-3;
Molecule name : STP 938; STP-938;
NCI Metathesaurus CUI : CL1921986;
Origin ID : C203257;
UMLS CUI : C5907993;
Semantic type(s)
- concept_is_in_subset
- has_target
