Preferred Label : CTPS1 Inhibitor STP938;
NCIt synonyms : Cytidine Triphosphate Synthase 1 Inhibitor STP938;
NCIt definition : An orally bioavailable, small molecule inhibitor of cytidine triphosphate synthase
1 (CTPS1), with potential antineoplastic activity. Upon oral administration, CTPS1
inhibitor STP938 targets, binds to and inhibits the activity of CTPS1, thereby decreasing
the production of cytidine triphosphate (CTP), an essential building block of deoxyribonucleic
acid (DNA) and ribonucleic acid (RNA). This may disrupt DNA and RNA synthesis and
trigger apoptosis. CTPS1, an enzyme that catalyzes the rate-limiting step in pyrimidine
synthesis, plays an important and nonredundant role in B-cell and T-cell proliferation.
CTPS1 is required for rapid cell division in certain types of cancers that arise from
blood cells.;
Molecule name : STP 938; STP-938;
NCI Metathesaurus CUI : CL1921986;
Origin ID : C203257;
UMLS CUI : C5907993;
Semantic type(s)
- concept_is_in_subset
- has_target
