Preferred Label : Rezatapopt;
NCIt synonyms : Mutant p53 Activator PC14586; p53 Y220C Mutant Reactivator PC14586;
NCIt definition : An orally bioavailable, small molecule reactivator of the p53 Y220C mutant, with potential
antineoplastic activity. Upon oral administration, rezatapopt selectively targets
and binds to the crevice created by the p53 Y220C mutation, which normalizes and restores
wild-type p53 protein structure and activity. This blocks tumor cell cycle progression
and induces apoptosis in tumor cells expressing the p53 Y220C mutant. The p53 gene,
a tumor suppressor gene, is mutated in many tumor types. The p53 protein plays a key
role in the regulation of apoptosis and cellular proliferation.;
UNII : 5W59S33KC9;
CAS number : 2636846-41-6;
Molecule name : PC 14586; PC-14586;
NCI Metathesaurus CUI : CL1922184;
Origin ID : C203051;
UMLS CUI : C5908942;
Semantic type(s)
- concept_is_in_subset
- has_target
