NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1)
monoclonal antibody directed against integrin beta-6 (IB6) conjugated, via a protease-cleavable
linker, to the microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE),
with potential antineoplastic activity. Upon administration, the antibody moiety of
sigvotatug vedotin targets and binds to IB6 on the surface of tumor cells. Following
internalization, linker cleavage and the release of MMAE, MMAE targets and binds to
tubulin, and inhibits microtubule polymerization. This results in G2/M phase cell
cycle arrest and apoptosis in IB6-expressing tumor cells. IB6 is overexpressed in
certain cancer cell types and has been associated with increased proliferation, migration
and invasion of tumor cells.;
Currated CISMeF NLP mapping