Preferred Label : Engineered Interferon ORB-011;
NCIt synonyms : Engineered Cytokine ORB-011; Engineered IFN ORB-011; Cis-targeted Interferon ORB-011;
NCIt definition : An attenuated, cis-targeted interferon (IFN), with potential immunostimulating and
antineoplastic activities. Upon administration, engineered IFN ORB-011 specifically
targets, binds to and activates type 1 conventional dendritic cell (cDC1). As these
are specific immune cells that specialize in presenting tumor antigens to, and activating,
tumor cytotoxic CD8 T cells, ORB-011 may be able to stimulate a specific cytotoxic
T-lymphocyte (CTL)-mediated anti-tumor immune response. ORB-011 is engineered in such
a way as to minimize off-target IFN-based binding and thereby avoiding systemic toxicity.;
Molecule name : ORB 011; ORB-011;
Origin ID : C203003;
concept_is_in_subset
