Acridine - CISMeF

Preferred Label : Acridine;

NCIt definition : A polycyclic aromatic dye with antineoplastic, antimicrobial and imaging activities. Acridine and its derivatives intercalate within DNA and RNA by forming hydrogen-bonds and stacking between base pairs resulting in DNA crosslinks and strand breaks. In addition, acridine and its derivatives are a potent inhibitor of topoisomerase II enzyme. This results in the inhibition of DNA and RNA synthesis, predominantly occurring during S phase of the cell cycle and ultimately leads to cell death.;

UNII : 42NI1P5Q1X;

CAS number : 260-94-6;

ChEBI ID : CHEBI:36420;

Details

Origin ID

C203;

UMLS CUI

C4721520;

See also inter- (CISMeF)
- Product containing acridine (product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Acridine (substance) [SNOMED CT concept]
- Product containing acridine (product) [SNOMED CT concept]
- acridines [MeSH Descriptor]
- acridines [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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