Preferred Label : Ligand Directed Degrader BMS-986460;
NCIt synonyms : LDD BMS-986460; Ligand-directed Degrader BMS-986460;
NCIt definition : A ligand directed degrader (LDD) composed of an E3 ubiquitin ligase-binding moiety
that is conjugated, via a linker, to an as of yet undisclosed moiety that targets
a prostate specific tumor-associated antigen (TAA), with potential antineoplastic
activity. Upon administration, LDD BMS-986460 specifically and simultaneously targets
and binds to the TAA on prostate tumor cells and to E3 ubiquitin ligase, thereby creating
a ternary complex. This induces E3 ligase ubiquitination and proteasome-mediated degradation
of the TAA. This prevents TAA-mediated signaling and leads to an inhibition of the
growth of tumor cells that overexpress the unidentified TAA.;
Molecule name : BMS-986460; BMS 986460;
NCI Metathesaurus CUI : CL1922121;
Origin ID : C202988;
UMLS CUI : C5907986;
Semantic type(s)
- concept_is_in_subset
