Primary Head and Neck Mucosal CD30-Positive T-Cell Lymphoproliferative Disorder

Preferred Label : Primary Head and Neck Mucosal CD30-Positive T-Cell Lymphoproliferative Disorder;

NCIt synonyms : Primary Mucosal CD30-Positive T-Cell Lymphoproliferative Disorder;

NCIt definition : A spectrum of T-cell lymphoproliferative disorders that arise from the mucosal sites of the head and neck. They are characterized by the presence of CD30-positive neoplastic lymphoid cells with pleomorphic nuclei and abundant cytoplasm. Cells that resemble the hallmark cells of anaplastic large cell lymphoma are often seen. The lesions usually arise from the oral cavity and, less frequently, the conjunctiva, orbit, and nasopharynx. In most cases complete remission is achieved, following excision, with or without radiotherapy, and with or without systemic chemotherapy.;

Neoplastic status : Undetermined;

NCI Metathesaurus CUI : CL1922099;

Details

Origin ID

C202953;

UMLS CUI

C5908868;

Disease excludes abnormal cell
- Neoplastic B-Lymphocyte [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Precursor Natural Killer Cell [NCIt concept]
- Precursor T-Lymphoblast [NCIt concept]
Has associated anatomic sites
- Head and Neck [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
- Neoplastic T-Lymphocyte [NCIt concept]
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
disease_has_finding
- CD30-Positive Neoplastic Cells Present [NCIt concept]
- Primary Lesion [NCIt concept]
disease_has_normal_cell_origin
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Peripheral (Post-Thymic) T-Lymphocyte and Natural Killer Cell [NCIt concept]
- T-Lymphocyte and Natural Killer Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
- Mucosa [NCIt concept]
disease_has_primary_anatomic_site
- Head and Neck [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Clonal T-Cell Receptor Beta Chain Gene Rearrangement [NCIt concept]
- Clonal T-Cell Receptor Gamma Chain Gene Rearrangement [NCIt concept]

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