Preferred Label : G-Quadruplex-selective Transcription Inhibitor QN-302;
NCIt synonyms : Cell Penetrating and Capsase-9/PP2A Interaction Interfering Peptide PEP-010; G4 Transcription Inhibitor QN-302;
NCIt related terms : QN-302;
NCIt definition : A naphthalene diimide (ND) derivative and selective G-quadruplex (G4) transcription
inhibitor, with potential antineoplastic activity. Upon administration, QN-302 targets
and binds to highly stable G-quadruplex DNA sequences that are prevalent within the
promoter regions of cancer-related genes, thereby further stabilizing these complexes.
This stabilization prevents unwinding and inhibits transcription factor binding, which
leads to an inhibition of target gene transcription and expression and decreases G4-expressing
cancer cell proliferation. Specifically, QN-302 downregulates the expression of the
S100P gene in tumor cells. S100P, forming many quadruplex-forming sequences, plays
a key role in the proliferation and motility pathways in several cancers and is upregulated
in various tumor cell types. G4 sequences are over-represented in the promoter regions
of many oncogenes.;
UNII : 86Y5JME9KT;
CAS number : 2546091-70-5;
Molecule name : SOP-1812; QN-302; QN 302; SOP 1812;
NCI Metathesaurus CUI : CL1922081;
Origin ID : C202934;
UMLS CUI : C5854072;
Semantic type(s)
- concept_is_in_subset
