Preferred Label : Anti-GPC3 CAR T-lymphocytes AZD5851;
NCIt synonyms : Anti-GPC3 CAR T-cells AZD5851; Anti-GPC3 CAR-T Cells AZD5851;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a chimeric
antigen receptor (CAR) specific for glypican-3 (GPC3), with potential immunostimulating
and antineoplastic activities. Upon administration, anti-GPC3 CAR T-lymphocytes AZD5851
specifically target and bind to GPC3-expressing tumor cells, resulting in tumor cell
lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is
overexpressed on certain tumor cell types while minimally expressed in normal, healthy
cells; GPC3 plays an important role in cellular proliferation and differentiation.;
Molecule name : AZD-5851; AZD 5851;
Origin ID : C202932;
concept_is_in_subset
- has_target
