Preferred Label : Multi-kinase Inhibitor ST-1898;
NCIt synonyms : Multi-target Tyrosine Kinase Inhibitor ST-1898;
NCIt definition : An orally bioavailable small molecule inhibitor of multiple receptor tyrosine kinases
(RTKs), with potential antineoplastic activity. Upon oral administration, multi-kinase
inhibitor ST-1898 inhibits the activity of multiple RTKs, which may include vascular
endothelial growth factor receptor 2 (VEGFR-2; VEGFR2), hepatocyte growth factor receptor
(HGFR; c-Met), AXL (UFO), platelet-derived growth factor receptor alpha (PDGFRa),
rearranged during transfection (RET) and mast/stem cell factor receptor c-Kit (SCFR;
CD117). This may result in antitumor activity in tumor cells in which these RTKs are
upregulated or dysregulated.;
Molecule name : ST 1898; ST-1898;
Origin ID : C202906;
concept_is_in_subset
