Multi-kinase Inhibitor ST-1898

Preferred Label : Multi-kinase Inhibitor ST-1898;

NCIt synonyms : Multi-target Tyrosine Kinase Inhibitor ST-1898;

NCIt definition : An orally bioavailable small molecule inhibitor of multiple receptor tyrosine kinases (RTKs), with potential antineoplastic activity. Upon oral administration, multi-kinase inhibitor ST-1898 inhibits the activity of multiple RTKs, which may include vascular endothelial growth factor receptor 2 (VEGFR-2; VEGFR2), hepatocyte growth factor receptor (HGFR; c-Met), AXL (UFO), platelet-derived growth factor receptor alpha (PDGFRa), rearranged during transfection (RET) and mast/stem cell factor receptor c-Kit (SCFR; CD117). This may result in antitumor activity in tumor cells in which these RTKs are upregulated or dysregulated.;

Molecule name : ST 1898; ST-1898;

NCI Metathesaurus CUI : CL1922090;

Details

Origin ID

C202906;

UMLS CUI

C3661198;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ST1898 [MeSH concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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