Preferred Label : Engineered Interferon Alpha-2b Prodrug JZP898;
NCIt synonyms : Interferon Alpha-2b INDUKINE JZP898; INDUKINE Molecule JZP898; Engineered IFN-alpha-2b Prodrug JZP898;
NCIt definition : An engineered, prodrug form of the human cytokine interferon alpha-2b (IFN-alpha-2b),
composed of IFN-alpha-2b linked to a high affinity blockade element via a tumor protease-sensitive
linker, and a half-life extension domain, with potential immunomodulatory and antineoplastic
activities. Upon administration of engineered IFN-alpha-2b prodrug JZP898, IFN-alpha-2b
is bound to the blockade element and pharmacologically inactive. Upon proteolytic
cleavage in the tumor microenvironment (TME), active IFN-alpha-2b is released. IFN-alpha-2b
binds to specific IFN cell-surface receptors. This activates IFN-mediated signal transduction
pathways and induces the transcription and translation of genes with interferon-stimulated
response elements (ISREs); the protein products mediate immunomodulating and antiproliferative
effects. The selective activation in the TME enhances the IFN-alpha-2b-mediated immune
responses against tumor cells while sparing the unwanted effects of systemic, peripheral
immune activation. The inclusion of the half-life extension domain prolongs the agent's
exposure in the tumor.;
Molecule name : WTX-613; JZP 898; WTX 613; JZP-898;
NCI Metathesaurus CUI : CL1922089;
Origin ID : C202905;
UMLS CUI : C5907981;
Semantic type(s)
- concept_is_in_subset
