Preferred Label : KIT Non-Exon 9 Mutation;
NCIt synonyms : KIT Proto-Oncogene Tyrosine Protein Kinase Gene Non-Exon 9 Mutation; CD117 Non-Exon 9 Mutation; v-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog Gene Non-Exon 9 Mutation; KIT Non-Exon 9 Gene Mutation; c-KIT Non-Exon 9 Mutation;
NCIt definition : A change in the nucleotide sequence of the KIT gene that occurs outside of exon 9.;
NCIt note : KIT exon 9 mutations are the second most common mutation in gastrointestinal stromal
tumors (GISTs). Compared with those tumors bearing non-exon 9 mutations, GISTs with
exon 9 mutations in the KIT gene have a lower response rate and a shorter response
to standard dose of imatinib therapies and need to be treated with either higher doses
of imatinib or sunitinib-based regimens. (The Life Raft Group);
NCI Metathesaurus CUI : CL1921498;
Origin ID : C202673;
UMLS CUI : C5908671;
Semantic type(s)
- concept_is_in_subset
- molecular_abnormality_involves_gene
