CD33-specific CAR Lentiviral Vector-transduced Allogeneic T-lymphocytes

Preferred Label : CD33-specific CAR Lentiviral Vector-transduced Allogeneic T-lymphocytes;

NCIt synonyms : Allogeneic Anti-CD33 Chimeric Antigen Receptor T Cells; Allogneic Anti-CD33 CAR-T Cells; Allogeneic CD33-CAR-T Cells;

NCIt definition : A preparation of allogeneic T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the CD33 antigen, with potential immunomodulating and antineoplastic activities. Upon administration, CD33-specific CAR lentiviral vector-transduced allogeneic T-lymphocytes target and induce selective toxicity in CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia cells.;

Details

Origin ID

C202648;

chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Myeloid Cell Surface Antigen CD33 [NCIt concept]

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