Preferred Label : Allogeneic Natural Killer Cells IDP-023;
NCIt synonyms : Allogeneic NKs IDP-023; Allogeneic NK Cells IDP-023;
NCIt definition : A preparation of off-the-shelf (OTS) allogeneic, natural killer (NK) cells that contains
g minus NK cells (G-NKs), with potential cytolytic and antineoplastic activities.
Upon administration, allogeneic NK cells IDP-023 recognize and lyse cancer cells.
These cells also secrete pro-inflammatory cytokines, which further stimulate an anti-tumor
immune response. G-NKs are deficient in the FceR1g protein and show increased cytokine
secretion, higher levels of cytolytic enzymes, increased persistence, and higher antibody
dependent cell mediated cytotoxicity (ADCC) when combined with monoclonal antibody
treatment.;
Molecule name : IDP 023; IDP-023;
NCI Metathesaurus CUI : CL1921872;
Origin ID : C202601;
UMLS CUI : C5907976;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
