DNA Interstrand Cross-Link Repair

Preferred Label : DNA Interstrand Cross-Link Repair;

NCIt synonyms : Repair of DNA Interstrand Cross-Links;

NCIt definition : DNA interstrand cross-links (ICLs) are very toxic to dividing cells, because they induce mutations, chromosomal rearrangements and cell death. A number of multi-step DNA repair pathways including nucleotide excision repair, homologous recombination and post-replication/translesion repair all impinge on their repair.;

Details

Origin ID

C20225;

UMLS CUI

C1511673;

Semantic type(s)
- Genetic Function [UMLS semantic type]
biological_process_involves_gene_product
- 5' Exonuclease Apollo [NCIt concept]
biological_process_is_part_of_process
- Cell Survival [NCIt concept]
biological_process_results_from_biological_process
- DNA Interstrand Crosslinking [NCIt concept]
process_involves_gene
- DCLRE1B Gene [NCIt concept]
- DCLRE1B wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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