Preferred Label : Lipid Nanoparticle Encapsulated mRNA Encoding Human Single-chain IL-12 ABO2011;
NCIt synonyms : LNP-encapsulated mRNA Encoding IL-12 ABO2011;
NCIt definition : A formulation consisting of lipid nanoparticle (LNP)-encapsulated messenger RNA (mRNA)
encoding human single-chain interleukin-12 (scIL-12), with potential immunomodulatory
and antineoplastic activities. Upon intratumoral injection, the LNP moiety binds to
the plasma membrane of nearby cells and releases the scIL-12 mRNA into the cells.
The mRNA is then translated by the cellular protein translation machinery to produce
scIL-12, which is secreted into the local tumor microenvironment (TME). IL-12 activates
the immune system by promoting the secretion of interferon-gamma (IFN-g), activating
natural killer cells (NKs), and inducing cytotoxic T-lymphocyte (CTL) responses, which
may result in both decreased tumor cell proliferation and enhanced immune-mediated
destruction of tumor cells.;
Molecule name : ABOD 2011; ABOD-2011; ABO-2011; ABO 2011;
Origin ID : C202248;
concept_is_in_subset
