Preferred Label : IL-12-Fc Fusion Protein KGX101;
NCIt synonyms : IL-12 Fc Fusion Protein KGX101;
NCIt definition : An engineered fusion protein composed of the human pro-inflammatory cytokine interleukin-12
(IL-12) fused to a Fc domain and masked with protein domains, with potential immunomodulatory
and antineoplastic activities. Upon administration of IL-12-Fc fusion protein KGX101,
IL-12 is bound to the proteins and pharmacologically inactive. IL-12 does not become
active until cleaved by tumor-specific matrix metalloproteinases in the tumor microenvironment
(TME). Upon proteolytic cleavage, unbound and active IL-12 locally activates the immune
system by promoting the secretion of interferon-gamma (IFN-g) and activating CD8
T-cells, CD4 T-cells and natural killer cells (NKs). The activation and expansion
of these immune cells mediate cytolytic immune responses against tumor cells, thereby
killing tumor cells and inhibiting tumor cell proliferation. The Fc domain prolongs
the half-life and exposure in the tumor.;
Molecule name : KGX-101; KGX 101;
Origin ID : C202246;
concept_is_in_subset
