Preferred Label : GPRC5D/BCMA/CD3-targeting T-cell Engager IBI3003;
NCIt synonyms : GPRC5D/BCMA/CD3-targeted Agent IBI3003; GPRC5D/BCMA/CD3-targeting Agent IBI3003; T-cell Engager IBI3003; TCE IBI3003; GPRC5D/BCMA/CD3-targeting TCE IBI3003;
NCIt definition : A T-cell engager (TCE) targeting the tumor-associated antigens (TAAs) B-cell maturation
antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and
G-protein coupled receptor family C group 5 member D (GPRC5D), and the T-cell surface
antigen CD3, with potential antineoplastic activity. Upon administration, GPRC5D/BCMA/CD3-targeting
TCE IBI3003 binds to CD3 expressed on T-cells, and BCMA and GPRC5D expressed on tumor
cells. This results in the cross-linking of T-cells and tumor cells, and induces a
potent cytotoxic T-lymphocyte (CTL) response against BCMA- and GPRC5D-expressing tumor
cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell
activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily
(TNFRSF). BCMA, found on the surfaces of plasma cells and overexpressed on malignant
plasma cells, plays a key role in plasma cell proliferation and survival. GPRC5D is
overexpressed in certain malignancies, such as multiple myeloma, while minimally expressed
in normal, healthy cells. It plays a key role in tumor cell proliferation.;
Molecule name : IBI 3003; IBI-3003;
NCI Metathesaurus CUI : CL1921206;
Origin ID : C202244;
UMLS CUI : C5907965;
Semantic type(s)
- concept_is_in_subset
- has_target
