Preferred Label : GPC3-targeted Plasmid DNA Vaccine NWRD06;
NCIt definition : A plasmid DNA therapeutic cancer vaccine encoding glypican-3 (GPC3), with potential
immunomodulating and antineoplastic activities. Upon intramuscular administration
of GPC3-targeted plasmid DNA vaccine NWRD06 and following electroporation, the plasmids
enter the cells, and the cells express GPC3 and elicit a GPC3-specific cytotoxic T-lymphocyte
(CTL) immune response against tumor cells expressing GPC3. GPC3, a heparan sulfate
proteoglycan and a member of the glypican family, is overexpressed on certain tumor
cell types while minimally expressed on normal, healthy cells; GPC3 plays an important
role in cellular proliferation and differentiation.;
Molecule name : NWRD 06; NWRD-06;
Origin ID : C202243;
concept_is_in_subset
- has_target
