Preferred Label : hGH Gene;
NCIt synonyms : Human Growth Hormone Gene;
NCIt definition : HGH Genes (Somatotropin/Prolactin Family) share a high degree of sequence identity
and encode alternatively spliced diverse isoforms of Growth Hormone, a small secreted
peptide hormone that affects gene expression, metabolism, and growth control. Due
to alternative splicing, differential posttranslational modifications, optional binding
to GHBP or alpha2-macroglobulin, and potential proteolytic processing, circulating
GH shows great heterogeneity as a disulfide-linked or non-covalently associated monomer,
dimer, trimer, tetramer, or pentamer in homopolymeric and heteropolymeric combinations.
GH stimulates the liver and other tissues to secrete IGF-1. GH stimulates amino acid
uptake and protein synthesis in muscle and other tissues and stimulates differentiation
and proliferation of myoblasts. GH also stimulates mitosis, cell growth, and differentiation
of other cell types. (NCI);
Origin ID : C20223;
UMLS CUI : C1337049;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- gene_found_in_organism
- gene_plays_role_in_process
