Preferred Label : Anti-CD147 Monoclonal Antibody DS-1471;
NCIt definition : A monoclonal antibody directed against the tumor-associated antigen (TAA) CD147 (Basigin;
EMMPRIN; extracellular matrix metalloproteinase inducer; OX47; 5A11), with potential
antineoplastic activity. Upon administration, anti-CD147 monoclonal antibody DS-1471
targets and binds to CD147, thereby inhibiting the binding of CD147 to its binding
molecules and CD147 molecular chaperone functions. This inhibits CD147-mediated stabilization
and recycling of various CD147-binding proteins, including CD44, integrins, and monocarboxylate
transporter 1 (MCT1), and inhibits downstream signal transduction pathways mediated
by these proteins. This may lead to cancer cell death. CD147, a cell-surface glycoprotein
of the immunoglobulin G (IgG) superfamily, is overexpressed in certain human tumors
and plays an important role in tumor cell proliferation, migration, progression, and
metastasis.;
Molecule name : DS-1471a; DS-1471; DS 1471;
Origin ID : C202227;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
