NCIt definition : A metabolic disorder caused by polymorphisms in the LPA gene that affect the number
of kringle-4 repeats in the encoded protein, apolipoprotein(a) (apo(a)). The number
of kringle-4 repeats are inversely correlated with apo(a) expression in the blood.
Thus, forms of apo(a) with fewer repeats are expressed at elevated levels, which leads
to increased concentrations of apo(a)-containing lipoprotein particles and an elevated
risk for atherosclerosis, cardiovascular disease, and coronary artery disease.;
Semantic type(s)