Preferred Label : Allogeneic Anti-CD33 CAR T-cells VCAR33;
NCIt synonyms : Donor-Derived Anti-CD33 CAR T Cells VCAR33; Allogeneic Anti-CD33 CAR-T Cells VCAR33;
NCIt definition : A preparation of allogeneic T-lymphocytes, derived from the same matched healthy donor
who provided a stem cell transplant and transduced with a lentiviral vector to express
a chimeric antigen receptor (CAR) specific for the CD33 antigen, with potential immunomodulating
and antineoplastic activities. Upon administration, allogeneic anti-CD33 CAR T-cells
VCAR33 specifically recognize and kill CD33-expressing tumor cells. CD33 is expressed
on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid
leukemia cells.;
Molecule name : VCAR 33; VCAR-33;
NCI Metathesaurus CUI : CL1921438;
Origin ID : C202016;
UMLS CUI : C5907943;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
