Preferred Label : Aclarubicin;
NCIt synonyms : 1-naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5, 7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-((2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl)
-alpha-L-lyxo-hexopyranosyl]-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy]-, methyl
ester,(1R-(1alpha,2beta,4beta))-(9CI); Aclacinomycin A; (1R,2R,4S)-2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-alpha-L-lyxo-hexopyranosyl]-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy]-1-naphthacenecarboxylic
acid methyl ester; ACM-A; Aclacinomycin; Antibiotic MA144-A1; Aclacinomycin-A;
NCIt definition : An oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium
Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases
I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.
Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as
etoposide, teniposide and amsacrine. This agent is less cardiotoxic than doxorubicin
and daunorubicin.;
UNII : 74KXF8I502;
InChIKey : USZYSDMBJDPRIF-SVEJIMAYSA-N;
CAS number : 57576-44-0;
Molecule name : MA144-A1;
Chemical formula : C42H53NO15;
NSC code : 240619; 208734;
Codes from synonyms : NSC0208734; 9;
Origin ID : C202;
UMLS CUI : C0001143;
Automatic exact mappings (from CISMeF team)
- False automatic mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
