Preferred Label : Dual-activating Polyvalent STING Agonist ONM-501;
NCIt synonyms : STING-activating Polymer-encapsulated STING Agonist ONM-501; PC7A-encapsulated cGAMP ONM-501; PC7A-encapsulated STING Agonist ONM-501;
NCIt definition : A nanoparticle-based formulation consisting of the stimulator of interferon genes
protein (STING; transmembrane protein 173; TMEM173)-activating, pH-sensitive, polymeric
micelles PC7A, loaded with the endogenous STING agonist cGAMP, with potential immunoactivating
and antineoplastic activities. Upon intratumoral administration of dual-activating
polyvalent STING agonist ONM-501, both the polymer PC7A and the encapsulated cGAMP
target and bind to STING, thereby activating the STING pathway in immune cells in
the tumor microenvironment (TME). This leads to the production of pro-inflammatory
cytokines, including interferons (IFNs), enhances the cross-presentation of tumor-associated
antigens (TAAs) by dendritic cells (DCs), and induces a cytotoxic T-lymphocyte (CTL)-mediated
immune response against cancer cells. STING, a transmembrane protein that activates
immune cells in the TME, plays a key role in the activation of the innate immune system.;
Molecule name : ONM-501; ONM 501;
Origin ID : C201982;
concept_is_in_subset
- has_target
