A-Type Potassium Channel Modulatory Protein DPP6

Preferred Label : A-Type Potassium Channel Modulatory Protein DPP6;

NCIt synonyms : DPP6; Dipeptidyl Peptidase 6; Dipeptidyl Peptidase IV-Related Protein; Dipeptidyl Peptidase VI; DPP VI; DPPX; Dipeptidyl Aminopeptidase-Related Protein; Dipeptidyl Aminopeptidase IV-Related Protein; Dipeptidyl Peptidase IV-Like Protein; Dipeptidyl Peptidase-Related Protein;

NCIt related terms : DIPEPTIDYL AMINOPEPTIDASE-LIKE PROTEIN 6;

NCIt definition : A-type potassium channel modulatory protein DPP6 (865 aa, 98 kDa) is encoded by the human DPP6 gene. This protein is involved in the modulation of both Kv4 (KCND) family protein localization and voltage-activated A-type potassium ion channel activity.;

Alternative definition : CDISC: An antigen encoded by the DPP6 gene that binds to and regulates the biophysical characteristics of voltage-gated potassium channels. It can be considered as an autoantigen and is commonly associated with autoimmune encephalitis.;

NCIt note : Dipeptidyl aminopeptidase-like protein 6 has no aminopeptidase activity due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases.;

NCI Metathesaurus CUI : CL1921393;

Details

Origin ID

C201943;

UMLS CUI

C1611457;

OMIM relation
- Dipeptidyl peptidase VI [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- DPP6 protein, human [MeSH Supplementary Concept]
- DPP6 protein, human [MeSH concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- DPP6 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Ion Transport Process [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]
- Transmembrane Transport [NCIt concept]
- Voltage-Gated Potassium Ion Channel Activation [NCIt concept]

Keyword's position in hierarchy(ies) :

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