Preferred Label : Anti-nectin-4 Antibody-drug Conjugate ADRX-0706;
NCIt synonyms : Anti-nectin-4 ADC ADRX-0706; ADC ADRX-0706; Anti-nectin-4/AP052 Antibody-drug Conjugate ADRX-0706;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the cell surface adhesion molecule and tumor-associated antigen (TAA) nectin-4 (PVRL4)
that is conjugated to the tubulin inhibitor and cytotoxic agent AP052, with potential
antineoplastic activity. Upon administration of the anti-nectin-4 ADC ADRX-0706, the
anti-nectin-4 antibody targets and binds to nectin-4 expressed on tumor cells. Upon
binding and internalization, AP052 targets and binds to tubulin, and inhibits its
polymerization. This results in G2/M phase arrest and induces apoptosis in nectin-4-expressing
tumor cells. Nectin-4, a TAA belonging to the nectin family, is overexpressed in a
variety of cancers, but has a restricted distribution in normal tissue. It is associated
with poor disease prognosis. ADRX-0706 has a drug-antibody ratio (DAR) of eight.;
Molecule name : ADRX 0706; ADRX-0706;
Origin ID : C201920;
concept_is_in_subset
- has_target
