Preferred Label : Transcription Factor Protein SON-DP;
NCIt synonyms : TF Protein SON-DP;
NCIt definition : A transcription factor (TF) protein, with potential antineoplastic activity. Upon
administration, TF protein SON-DP induces pluripotent reprogramming in cancer cells
and generates transient induced pluripotent stem cells (tiPSCs). The in situ generated
tiPSCs quickly re-differentiate into normal tissue cells. The tiPSCs also secrete
exosomes, which provides embryonic stem cells (ESC)-like microenvironments. This may
result in malignant phenotype reversion in the surrounding cancer cells. In addition,
the tiPSCs may revert distant metastatic cancer cells into normal cells through tropism
effect.;
Molecule name : SON-DP;
NCI Metathesaurus CUI : CL1920688;
Origin ID : C201813;
UMLS CUI : C5907930;
Semantic type(s)
- concept_is_in_subset
