Preferred Label : CD19-expressing Oncolytic Virus CF33;
NCIt synonyms : CD19-expressing OV CF33; CF33-CD19; Oncolytic Virus CF33-expressing CD19; OnCARlytics (TM); OV CF33-expressing CD19;
NCIt definition : A genetically modified oncolytic virus (OV) composed of CF33, a replication competent
orthopoxviral chimera that is engineered to express the tumor-associated antigen (TAA)
CD19, with potential oncolytic, immunostimulating and antineoplastic activities. CD19-expressing
OV CF33 is used in combination with certain anti-CD19 agents, such as anti-CD19 chimeric
antigen receptor (CAR) T-cells or anti-CD19 bispecific antibodies. Upon intratumoral
(IT) or intravenous (IV) administration of CD19-expressing OV CF33, the oncolytic
virus specifically binds to, infects and replicates in tumor cells, leading to viral-mediated
tumor cell lysis. The released virus particles, in turn, infect and replicate in neighboring
tumor cells. Tumor antigens released from the lysed tumor cells also activate the
immune system to induce a tumor-specific systemic immune and cytotoxic T-lymphocyte
(CTL) response, thereby killing nearby non-infected tumor cells. In addition, the
CD19 antigen expressed by the OV is specifically delivered to and produced in the
infected tumor cells. As CD19 is presented on the tumor cell surface, the tumor cells
are tagged with CD19. This allows, upon the administration of certain agents that
target CD19, the specific eradication of CD19-expressing tumor cells.;
Origin ID : C201773;
concept_is_in_subset
