Preferred Label : Allogeneic Anti-NY-ESO-1-TCR-IL-15-transduced Cord Blood-derived Natural Killer Cells;
NCIt synonyms : Cord Blood-derived NK Cells Genetically Engineered with NY-ESO-1 TCR/IL-15 NKs; Allogeneic Anti-NY-ESO-1 TCR-transduced IL-15-expressing CB-derived NK cells;
NCIt definition : A preparation of allogeneic, umbilical cord blood (CB)-derived natural killer cells
(NKs) that have been engineered to express a T-cell receptor (TCR) specific for the
tumor-associated antigen (TAA) human cancer-testis antigen NY-ESO-1 and interleukin-15
(IL-15), with potential immunostimulating and antineoplastic activities. Upon administration,
the allogeneic anti-NY-ESO-1-TCR-IL-15-transduced CB-derived NKs target, bind to and
induce selective cytotoxicity in NY-ESO-1-expressing tumor cells. NY-ESO-1 is found
in normal testis and on the surface of various tumor cell types. IL-15 is a pro-survival
cytokine that promotes persistence of multiple lymphocyte lineages and potentiates
the immune response against tumor cells.;
Origin ID : C201721;
concept_is_in_subset
- has_target
