Preferred Label : EGFR/HER2 Mutant-selective Inhibitor STX-721;
NCIt synonyms : EGFR/HER2 Inhibitor STX-721;
NCIt definition : An orally bioavailable, mutant-selective, small molecule inhibitor of human epidermal
growth factor receptor (EGFR) and epidermal growth factor receptor 2 (HER2), with
potential antineoplastic activity. Upon oral administration, EGFR/HER2 mutant-selective
inhibitor STX-721 targets, binds to, and inhibits the activity of EGFR and HER2 with
exon20 insertion mutations, thereby preventing EGFR- and HER2-mediated signaling.
This may result in the inhibition of tumor growth and angiogenesis, and tumor regression
in EGFR/HER2-expressing tumors. EGFR and HER2, receptor tyrosine kinases mutated or
overexpressed in many tumor cell types, play major roles in tumor cell proliferation
and tumor vascularization.;
Molecule name : ST-5924; STX 721; ST 5924; STX-721;
Origin ID : C201690;
concept_is_in_subset
- has_target
