NCIt definition : Human GLUD1 wild-type allele is located in the vicinity of 10q23.2 and is approximately
45 kb in length. This allele, which encodes glutamate dehydrogenase 1, mitochondrial
protein, plays a role in the replenishment of alpha-ketoglutarate for use in the citric
acid cycle and the modulation of insulin secretion. Mutation of the gene is associated
with hyperinsulinism-hyperammonemia syndrome.;