Preferred Label : Anti-CD24 Monoclonal Antibody ATG-031;
NCIt definition : A humanized monoclonal antibody targeting the cell surface protein CD24, with potential
immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-CD24
monoclonal antibody ATG-031 targets and binds to CD24 expressed on tumor cells, thereby
blocking the interaction of CD24 with sialic acid-binding Ig-like lectin 10 (Siglec-10)
expressed on innate immune cells including tumor-associated macrophages (TAMs) in
the tumor microenvironment (TME). This prevents CD24/Siglec-10-mediated signaling
and abrogates the CD24/Siglec-10-mediated inhibition of macrophage-mediated phagocytosis
of tumor cells. This results in macrophage-dependent tumor cell phagocytosis, repolarization
from the immunosuppressive M2 subtype macrophages to the anti-tumor M1 subtype in
the TME, and the abrogation of the immunosuppressive TME. CD24, a glycophosphatidylinositol
(GPI)-anchored, highly glycosylated cell adhesion protein, is overexpressed on the
surface of a variety of cancer cells. Expression of CD24, and its interaction with
Siglec-10, protects cancer cells from phagocytosis, thereby allowing cancer cells
to proliferate.;
Molecule name : ATG-031; ATG 031;
NCI Metathesaurus CUI : CL1920837;
Origin ID : C201655;
UMLS CUI : C5907920;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
